Gastrointestinal Stromal Tumour (GIST) of Duodeno-Jejunal (DJ) Flexure with Gastrointestinal Bleeding: A Rare Case Report

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Gastrointestinal Stromal Tumour (GIST) of Duodeno-Jejunal (DJ) Flexure with Gastrointestinal Bleeding: A Rare Case Report

1Nagesh Madnoorkar, 2Pramod Shinde, 3Aarti Anvikar, 4Saylee Madnoorkar
1Kaushalya Hospital, Surgical Oncology, Nashik, India.
2Kaushalya Hospital, General Surgery, Nashik, India.
3Government Medical College, Pathology, Miraj, India.
4Government Medical College, Pathology, Miraj, India.


ABSTRACT:

GIST – Gastrointestinal stromal tumor is the most common mesenchymal tumor of the gastrointestinal tract with an annual incidence of 11-20% per 1 million people. In GIT, the most common site of presentation is the stomach (70%) followed by the small intestine (20-30%), remaining (10%) in the colon, rectum, and oesophagus. GIST occurs due to mutations in the receptor tyrosine kinase KIT gene. Few cases have mutations in the PDGFRA gene. Here we report a rare case of Duodeno-Jejunal (DJ) flexure GIST with a history of pain in the abdomen and melena. 

 

KEYWORDS:

Gastrointestinal bleeding, Gastrointestinal stromal tumour (GIST), DJ flexure, CD 117, C KIT

 

REFERENCES :

1) Kramer K, Siech M, Sträter J, Aschoff AJ, Henne-Bruns D. GI hemorrhage with fulminant shock induced by jejunal gastrointestinal stromal tumor (GIST) coincident with duodenal neuroendocrine carcinoma (NET) + neurofibromatosis (NF): case report and review of the literature. J Gastroenterol. 2005; 43(3):281-8.
2) Liu Z, Zheng G, Liu J, et al. Clinicopathological features, surgical strategy and prognosis of duodenal gastrointestinal stromal tumors: a series of 300 patients. BMC Cancer. 2018;18(1):563. doi:10.1186/s12885-018-4485-4.
3) Miettinen M, Lasota J. Gastrointestinal stromal tumors–definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch. 2001;438(1):1-12. doi:10.1007/s004280000338.
4) Addala PK, Swain SK, et al. Duodenojejunal flexure tumors: Surgical difficulties with case series. J Gastrointest Oncol. 2015;6(3):280-286.
5) Bansal M, et al. An intraluminal jejunal gastrointestinal stromal tumor near DJ flexure with gastrointestinal bleed: a rare case report. Int Surg J. 2017;4(10):3564-3566.

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